Hemostasis Imbalance in Experimental Hypertension

Hemostasis imbalance in experimental hypertension.

BACKGROUND The rat model of chronic intoxication by N(G) -nitro-L-arginine methyl ester (L-NAME) induces severe systemic arterial hypertension and progressive ischemic lesions in the central nervous system and kidneys. We investigated the possible molecular basis of these thrombotic events. METHODS AND RESULTS Administration of L-NAME increased plasma markers of thrombin generation, thrombin-...

Experimental Hypertension

Unilateral renal ischemia superimposed upon intestinal ischemia has resulted in a prolonged elevation in the arterial blood pressure in a high percentage of the animals which were studied.

Power Imbalance in Collaboration Relationships

Power plays a significant role in many organizational theories such as resource dependency theory and transaction cost economics. It allows the strong companies to win more than others, or more broadly, to coerce others to do what they would not otherwise do. Power can seriously affect the confidence and commitment between parties. This paper aims to analyze the power concept in inter-organizat...

Pravastatin attenuates hypertension, oxidative stress, and angiogenic imbalance in rat model of placental ischemia-induced hypertension.

Preeclampsia is a pregnancy-specific condition characterized by an imbalance of circulating angiogenic factors and new-onset hypertension. Although current treatment options are limited, recent studies suggest that pravastatin may improve angiogenic profile and reduce blood pressure in preeclampsia. We hypothesized pravastatin would restore angiogenic balance and reduce mean arterial pressure (...

Observational and Experimental Evidence of Imbalance in Destigmatization